Cat screams, growls and hisses very often. What can we do?

Is your female spayed? If not, it could be that she's in heat, which would be the reason she would be "screaming". Female cats in heat tend to get rather loud. It may be worse for her because she's in the presence of a male cat, though he's still young enough that he wouldn't know what mating is. Other than that, I have two cats myself, both female, and the younger one gets to be an annoyance to the older one sometimes, so the older one tends to "go off" on the younger one, and she'll do that sometimes even if the younger cat is anywhere near her. You might try separating them when you go to bed and see if that helps, or see if a spray bottle works too. Spray bottles don't work so well on my cats, but that's not to say it won't work on yours.